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it can inactivate the generation of pro-inflammatory mediators in microglia by affecting the NF-B, p38/MAPK and Nrf2/ARE-dependent signaling pathways, thus inhibiting activation of the immune response following cerebral ischemia (117)

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The present invention provides topical compositions to address conditions experienced by women in the menopausal state comprising a carrier and an effective amount of S-acyl glutathione derivative of the following formula: wherein R 1 is consists of a saturated or unsaturated aliphatic C 12 -C 24 group, preferably an unsaturated C 16 -C 24 group, more preferably an unsaturated C 18 group, most preferably, a linoleoyl group

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