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Accordingly, it has been reported that simvastatin has additive effect with the antiandrogen enzalutamide promoting a greater inhibition of prostate cancer cells (225, 226)

10.1038/nrm3931 196

Hormesis is featured with biphasic dose response, meaning that low doses of the stressor are neuroprotective, while high doses can exert a neurotoxic action in the brain

Its proposed mechanism is unusual: Selank appears to modulate the expression of GABA-A receptor genes without binding the benzodiazepine site , which is offered as an explanation for anxiolytic activity that comes without sedation, tolerance, dependence or withdrawal [3]