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10.1016/S0092-8674(03)00508-7 17 DanielsT

Besonders die folgenden Faktoren fhren dazu, dass die Menge an Glutathion im Krper schnell sinkt: Dauerstress und Termindruck: Bei anhaltender psychischer oder krperlicher Belastung entstehen vermehrt freie Radikale

GLYI and GLYII ( S -lactyl-glutathione (SLG) which is further hydrolysed by GLYII into D-lactate and GSH ( Figure 1 )

Second, NFE2L2 activation enhances the expression of SLC7A11, GCLM, CBS, CHAC1, ABCC1/MRP1, GCLC and GSS, which are involved in GSH production, metabolism and release