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KA is a glutamate receptor antagonist that blocks the NMDA receptor of glutamate and acts as a scavenger of free radicals, such as the hydroxyl radical or superoxide ( In the pathophysiology of depressive disorders, the involvement of the kynurenine pathway is more likely when reactive oxygen species are generated from 3-HK and QUIN acid

While the immune system can recognize and destroy cancer cells, tumors often develop mechanisms to evade immune surveillance [121]

Neurotransmitter Metabolites Dopamine, serotonin, and norepinephrine/epinephrine pathway metabolites

Multiple logistic regression analysis revealed that NQO1, particularly in amniotic fluid, showed the strongest association with Down syndrome, demonstrating good diagnostic performance with high sensitivity and specificity

Additionally, serum zinc concentrations decline with age, with a more significant reduction observed in patients with Alzheimer's disease (AD) than in healthy individuals of similar age (Brewer, 2012[52])