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(l) Chemogenetic inhibition (1 mg/kg CNO) of peri-LC GABA neurons decreased movement in OFT (p = 0.0231)

Parsad, D., Dogra, S

Figure 5 3.4 Analysis of the comprehensive proteomic signature of significant shared genes To further narrow the gene information and maximize the roles of important genes, comparative analysis based on topological algorithms was conducted, and a total of eight significant shared genes were obtained, namely, CLDN5, COL7A1, LDHA, MAP2K2, RETSAT, SEMA3A, TAGLN, and TBC1D1 ( Figure 6A )

Although less sensitive to hyperoxidation by H 2 O 2 than Prxs 1 and 2, Prx3 is rapidly hyperoxidized by lipid hydroperoxides [157,158]

Its distinct mechanism makes it ideal for combination studies with GLP-1 agonists like Semaglutide exploring synergistic effects on appetite, glucose control, and energy balance that neither pathway achieves alone