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Most nausea occurs here

Gao 2023 (human GLP1R-variant series) puts a number on it at the GLP-1 receptor: cAMP output saturates at roughly 10% (103%) receptor surface expression, so full effect sits far below full occupancy

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Similar to the Hb A 1c results, the change in triglyceride concentration depended upon the baseline value for the ARA 290 group (Figure 3A) but not for the placebo group (Figure 3B)