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Description

Figure 1 illustrates NNMT utilizing SAM as a methyl donor to methylate NAM, yielding MNAM and SAH

The intramolecular disulfide bond between its two cysteine residues is believed to be important for maintaining its active conformation

By reducing SAM consumption through NNMT inhibition, 5-Amino-1MQ helps preserve methylation capacity for other critical cellular processes, including DNA and histone methylation (epigenetic regulation), neurotransmitter synthesis, and phospholipid metabolism