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Phytother Res: PTR 22(10):13611366 Moses T, Papadopoulou KK, Osbourn A (2014) Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives

Inoue S, et al

In general, younger patients are better able to overcome acute liver failure as a result of APAP hepatotoxicity, probably due to the larger hepatic cell mass that is present in this population before the cell damage occurs, as well as the better capacity of those cells for non-toxic metabolism and their improved capacity for regeneration

And as I mentioned earlier, the type of water you use is very important

The answer depends on several factors, but most people should have no difficulty with either method