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In this regard, SGLT2 inhibitors might prevent cells exposure to oxidative stress and promote cellular repair via up-regulating energy deprivation sensors such as AMPK and SIRT1, as well as via inhibition of insulin/IGF-1 signaling [28]

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Lu Q, Yang L, Xiao JJ, Liu Q, Ni L, Hu JW, et al

SASP induction by senescent cancer cells can also improve tumor vascularization, a phenomenon that may be considered beneficial, as demonstrated in previous studies on PDAC cells [39]

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