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Therefore, inhibition of Grx2 would promote glutathionylation of the active site, causing SIRT1 inactivation and prevent angiogenesis [41]

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A phase Ib/II study of ivosidenib with venetoclax +/- azacitidine in IDH1-mutated myeloid malignancies

Oxidatieve stress leidt op zijn beurt tot schade aan cellen en weefsels en is daarom een belangrijke factor bij veel chronische ziekten

[DOI] [PubMed] [Google Scholar] 21.Khatib A., Solaimuthu B., Ben Yosef M., Abu Rmaileh A., Tanna M., Oren G., Schlesinger Frisch M., Axelrod J.H., Lichtenstein M., Shaul Y.D