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In cases of familial late-onset PD, 8.67% exhibited mutations in GBA (heterozygous), HTRA2, and SNCA, while 30.03% had disease-causing genes in CHCHD2, DJ-1, GBA (heterozygous), LRRK2, PINK1, and PRKN (Sun et al., 2023)

Inhibiting CypB in tendon appears to impair fibrillogenesis and collagen morphology by altering lysine hydroxylation of collagen molecules, potentially through modulation of LH1-3 selectivity and activity, alteration of the P3H complex, or modification of collagen-SLRP interactions (Kalamajski et al ., 2014

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