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Additionally, probiotic supplementations that are most associated with amelioration of NAFLD in patients and preclinical models all include members of the phylum Bacillota , likely representing partial restoration of a healthy gut microbiome (Safari and Grard, 2019)

[] In contrast to Fndc5, myonectin (CTRP15, also a myokine) activates mTOR to suppress autophagy in the liver, [] and CTRP15 deletion promotes fat storage in the adipose tissue and reduces hepatic steatosis