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This is a rare subgroup, representing only 1.4% of melanomas.[16] The etiology of mucosal melanomas remains unclear, but whole-genome sequencing reveals mutational signatures unrelated to UV radiation, which is distinct from cutaneous melanomas.[17] Diagnosis is often delayed due to the location of these lesions, a lack of symptoms, and potential amelanotic appearance.[18] There is no clear consensus on staging definitions for mucosal melanoma, and the AJCC eighth edition TNM (tumor, node, metastasis) staging is only used for head and neck mucosal melanomas.[10] The overall prognosis is poor and varies by location

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Managing skin cancer

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Genital skin biopsy is essential to make the diagnosis