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Tryptophan and arginine have become effective targets of tumor immunotherapy (amino acids contributing to tumor immunity are addressed in section Amino Acid Metabolism and Tumor Immunity)

The qPCR results and the enrichment map of the ferroptosis signaling pathway indicated that CTX primarily induces the upregulation of HO-1, leading to the accumulation of ferrous ions (Fig

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Contrary to expectations, this structural deviation correlates with enhanced radical scavenging activity, likely by influencing the accessibility and reactivity of its hydroxyl groups, although it may still reduce efficacy in some enzyme-binding contexts (Li et al., 2024)

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