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Mutation can change the binding site of imatinib to the BCRABL (break point cluster regionAbelson murine leukaemia viral oncogene homolog 1) gene, thereby inhibiting the activity of imatinib amongst patients who have chronic myeloid leukaemia [87, 88]

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The results showed no significant differences in the proportion of TUNEL-positive granulosa cells between the groups in primary and secondary follicles

An imbalance between SOD activity and GPX was proposed as an important determinant of molecular ageing, since the resultant hydroxyl radicals which are highly reactive could cause damage to macromolecules such as DNA, protein and lipids (Bar-Peled, Korkotian, Segal & Groner, 1996