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Mass spectrometry-based proteomics has shown that allicin modifies proteins like tubulin (TUBB, TUBA1), actin (ACTG), cofilin (CLF1), superoxide dismutase-1 (SOD-1), elongation factors (EEF2), heat shock proteins (HSP90, HSPA4), and glycolysis enzymes (ALDOA, GAPDH, PKM) in Jurkat cells

Biochemical analyses of ROS accumulation and antioxidant activity presented complex, mixed results - upregulation and downregulation, underscoring the need for deeper investigation into oxidative stress pathways

For this purpose, they stained brain slices using 3,3-diaminobenzidine (DAB), and tyrosine hydroxylase analyzed using a light microscope

9 , eadi9575 (2024)

Additionally, luteolin inhibits the phosphorylation of JAK1 (Janus kinase 1) and STAT3 (signal transducer and activator of transcription 3), which are vital components of the JAK/STAT signaling pathway