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We did significantly suppress peripheral inflammation, Jeffrey Cummings of the University of Nevada, Las Vegas, a lead investigator on the study, said at the 2025 Clinical Trials in Alzheimers Disease Conference

It considerably reduces cardiovascular events and improves inflammatory state and disease activity scores when used in conjunction with biologics for autoimmune diseases (such as RA and SLE) (274277)

Preclinical studies have shown that cobalamin inhibits glutamate exocytosis, as an excitatory pain neurotransmitter, and when infused intracerebroventricularly, increases GABA cell contents, as an inhibitory pain neurotransmitter [6, 9]

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