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Description

Springer International Publishing, 2017

Either Trx1 or Grx1 are required for each turnover of RNR, the essential enzyme for deoxyribonucleotides synthesis during DNA replication and repair

Among these, the MTHFR C677T variant has been most extensively studied, although findings from individual studies remain inconclusive, possibly due to underpowered cohorts [89, 90]

Since cPMP replacement therapy can only benefit MocoD Type A, additional treatment methods are required

Mitochondrial dysfunction leads to cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances and endothelial dysfunction, which all could play a role in long COVID