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Icariin improves osteoporosis, inhibits the expression of PPAR, C/EBP, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats

This oxidative stress contributes to both their antitumor activity and their notorious dose-limiting cardiotoxicity , as cardiac myocytes are especially susceptible to ROS due to relatively low levels of endogenous antioxidant enzymes like catalase

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doi: 10.3389/fimmu.2022.1049936 Received 21 September 2022 Accepted 07 November 2022 Published 21 November 2022 Volume 13 - 2022 Edited by Zhihao Jia, Purdue University, United States Reviewed by Jingbo Pang, University of Illinois at Chicago, United States