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The rest of this piece covers exactly how dosing scales across species, what reconstitution errors destroy peptide integrity, and what administration mistakes negate metabolic signalling entirely

-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia

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