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The prediction of subcellular localization was performed by compiling results obtained from various softwares as Predotar, TargetP, and Wolfpsort

Mechanistically, the activated MLKL can be localized in mitochondria, which may promote the formation of mitochondrial pores and the efflux of mtDNA into the cytoplasm, thereby promoting the activation of the cGAS-STING pathway in tumor cells after RT [282]

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