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This happens because ibuprofen reduces the elimination of methotrexate, leading to higher blood levels

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Furthermore, we showed that rv 1127c is more susceptible to bedaquiline (BDQ) than wild-type (WT) Mtb (Mackenzie et al, 2020), and therefore drugs targeting Rv1127c may synergise with BDQ, which is the backbone of the oral, shortened treatments for antibiotic-resistant TB

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doi: 10.1016/j.amjmed.2005.02.026

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