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the multi-arm PEG derivative is a tetra- or octa carboxy PEG

10.1016/S0959-440X(96)80036-4 9 FarnoodianM.HalbachC.SlingerC.PattnaikB

[25] In ovariectomized rats exposed to methylmercury, estradiol replacement reduced mercury accumulation in the pituitary gland and the hypothalamus, and protected the hormonal signaling axis from mercury-induced disruption