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Clinical studies show: Teeth become 2-3x less sensitive to cold air within 7 days Sensitivity to probing is reduced by 3-4x After 6 months, hypersensitivity decreases by up to 22x By contrast, traditional fluoride treatments often lose efficacy over time

Although several candidate drug resistance mechanisms, including impaired DNA repair, decreased drug uptake, increased drug efflux and detoxification, have been proposed (reviewed by Galluzzi et al, 2012), we are still some way from understanding the molecular basis of drug resistance, and from developing biomarkers to predict the onset and monitor the development of drug-resistant disease in cancer patients

doi:10.1146/annurev.bi.52.070183.003431

Animal studies have confirmed that subcutaneous injection in one body area produces collagen synthesis improvements, enhanced angiogenesis, and accelerated wound closure at sites far from the injection point

doi: 10.1007/bf01803560 45 DavisS