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Based on the collective data, we concluded that glutamate inhibited paravascular movement though the NMDA receptor, which was pulsation-dependent, and suppressed tracer penetration into the parenchyma and interstitial fluid drainage though the AMPA/kainate receptor which was AQP4-dependent

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Network pharmacology enhances the precision of drug discovery by linking pharmacological targets to disease mechanisms through target prediction algorithms and functional enrichment analyses, such as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway mapping (Singh et al., 2022)

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Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification