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Metabolism, Absorption, and Anti-cancer Effects of Sulforaphane: an Update

In pursuit of harmony, on behalf of European federation for clinical chemistry and laboratory medicine (EFLM) working group for preanalytical phase (WG-PRE)

The characteristics of how TnpB targets DNA have been documented, from the earliest classified ISDra2 TnpB, K, and racemifer TnpB types to the latest database-screened ISDge10, ISAam1, and ISYmu1 (Altae-Tran et al., 2021

Therefore, intracellular GSH depletion or GPX4 inactivation induced by various factors will decrease the clearance rate of toxic lipid peroxides and result in ferroptosis

Ferroptosis, a unique form of regulated cell death characterized by iron-dependent lipid peroxidation, significantly impacts immune cell function and inflammatory responses, contributing to the autoimmune disease process (87, 88, 141, 199, 200)