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Amino acids are the building blocks of protein which contributes to the maintenance and growth of muscle mass and maintenance of normal bones

These pathways are complex and involve communication between peripheral metabolic signals and central nervous system circuits

Specifically, TMAO blocks bile acid-activated farnesoid X receptor (FXR) signaling and reduces key bile acid synthesis enzymes (Cyp7a1, Cyp27a1), limiting bile acid production and increasing fatty liver risk (Koeth et al., 2013