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Sci Rep 10(6883):112

In an in vivo study comparing the blood glucose levels-lowering effects of saline, PO-free insulin solution, SC insulin solution, uncoated NCs, and pHPMA nanoparticles with the lowest charge density in diabetic rats, pHPMA nanoparticles demonstrated a maximal reduction of 50% in blood glucose levels, at 4 h post-administration with a dosage of 75 IU/kg

The different orientations of the drugs bound to each protein, as depicted in Figure 3 (left panel vs right panel), corroborate our observation of distinct levels of flexibility between the two proteins

There is clinical interest for kisspeptin use to induce ovulation with potentially fewer side effects than conventional agents and for its supportive role in assisted reproduction