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Modulation of Pain in Fibromyalgia (Fibrositis Syndrome): Cerebrospinal Fluid (CSF) Investigation of Pain Related Neuropeptides with Special Reference to Calcitonin Gene Related Peptide (CGRP)

In conclusion, both deleterious consequences of mitochondrial impairment, i.e., restricted ATP generating capacity and ROS production, impair UPS-dependent proteolysis in neurons and are highly relevant to the pathogenesis of AD

Furthermore, such guidelines can advance scientific research, help formulate more scientific and forward-looking treatment protocols, and enhance patient and public understanding and acceptance of the treatment options