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Total RNA of wheat shoots and roots were extracted by using TransZol RNA Isolation Reagent (Tiangen, China) and determined the concentration

Feldbrin et al., 2016)

Glossary SCD sickle cell disease OA osteoarthritis HH hereditary hemochromatosis HFE homeostatic iron regulator HAMP hepcidin antimicrobial peptide Tf transferrin TfR2 transferrin receptor-2 HJV hemojuvelin MMP13 matrix metalloproteinase-13 ADAMTS5 a disintegrin and metalloproteinase with thrombospondin motifs 5 KO knockout TNF- tumor necrosis factor- IL-1 interleukin-1 FAC ferric ammonium citrate ROS reactive oxygen species TfR transferrin receptor BMSCs bone marrow mesenchymal stem cells RANKL receptor activator of nuclear factor-kappa B ligand BMMs bone marrow-derived macrophages OPG osteoprotegerin DFO deferoxamine MAPK mitogen-activated protein kinase Runx2 runt-related transcription factor 2 DMT1 divalent metal transporter 1 PI3K phosphatidylinositol 3-kinase JAK janus kinase STAT3 signal transducer and activator of transcription 3 FLSs fibroblast-like synoviocytes RA rheumatoid arthritis ALP alkaline phosphatase OPN osteopontin

Zukor et al., 2009)