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As pesquisas pr-clnicas evidenciaram um amplo espectro de atividades biolgicas, incluindo a citoproteo gstrica, a modulao da via do xido ntrico (NO) e a interao com o sistema dopaminrgico

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It is known that the activation of all TRPs promotes the entry of Ca 2+ into the cell, which, in turn, triggers the activation of biochemical pathways, such as the calcium-dependent-phospholipase C (PLC) pathway (Kouchi et al., 2004), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP 2 ) into inositol 1,4,5-trifosfato (IP 3 ) and diacylglycerol (DAG) (Wang et al., 2020) and then IP 3 binds to IP 3 receptors located in the endoplasmic reticulum (ER), promoting a transient increase in cytosolic Ca 2+ (Curcic et al., 2019

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