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Peroxynitrite inactivates thiol-containing enzymes of Trypanosoma cruzi energetic metabolism and inhibits cell respiration

Research indicates that curcumin inhibits the migration and invasion of cancer cells by suppressing matrix metalloproteinases (MMP-2) and (MMP-9), which are enzymes that facilitate cancer spread by degrading the extracellular matrix (525, 526)

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Current status within peer-reviewed literature and laboratory investigative models

As the pedigree depicted autosomal recessive inheritance, homozygous and compound heterozygous variants were preferred but heterozygous variants were not ignored