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So those are always probably the toughest ones

Jin H, Liu C, Liu X, Wang H, Zhang Y, Liu Y, et al

HGF II stabilizes c-MET II-HGF I interaction by forming a tripartite interface In the majority of the particles, the second HGF (i.e., HGF II) adopts a flexible conformation with only its SPH domain, which contacts c-MET II-SEMA, being well resolved in the cryo-EM map