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How many times have you heard statements like these: None of the team members really believed that they could complete the project according to the schedule they were given, but they thought that maybe if everyone worked hard, and nothing went wrong, and they got a few lucky breaks, they just might be able to pull it off. Our team hasnt done very much work to coordinate the interfaces among the different parts of the product, but weve all been in good communication about other things, and the interfaces are relatively simple, so itll probably take only a day or two to shake out the bugs. We know that we went with the low-ball contractor on the database subsystem and it was hard to see how they were going to complete the work with the staffing levels they specified in their proposal

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The proteins TDP-43 and FUS are involved in managing RNA, and influencing thousands of genes, and their dysfunctioning severely impacts RNA splicing, stability, and export