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Hyperpolarized (13)C spectroscopic evaluation of oxidative stress in a rodent model of steatohepatitis

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This analogue also demonstrated the most pronounced detoxifying effect towards cisplatin action, resulting in a decrease in the animal death from the acute cisplatin toxicity to 17% (in comparison with 50-67% for the control animals) and restoration of a number of cisplatin-sensitive biochemical blood parameters: decrease in the activity of aspartate aminotransferase and alanine aminotransferase and downregulation of the concentration of the final products of nitrogen exchange (creatinine and urea)

In addition to oxidants that induce lipid peroxidation, inhibitors that prevent lipid peroxidation are also produced during normal metabolism

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