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Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]

Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia

Bedoui Y, Guillot X, Slambarom J, et al

It functions as the first line of defense against substances attempting to cross the BBB [31]

Among various cell surface receptors, IGF-1R (insulin-like growth factor receptor) expression is important for myoblast proliferation and maintenance of normal muscle mass 21,22,23,24,25,26