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When these pathways are disrupted such that total cellular iron levels rise, the pro-oxidant environment induces excessive lipid peroxidation, most notably of the fatty acyl moieties on phospholipids of poly unsaturated fats, resulting plasma membrane permeabilization and lytic cell death (150)

In summary, we identify dysregulated pathways and genes in each transgenic fish carrying LMNA variants and disclose their influence on physiological systems

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