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Nutrients 17(2)

Notably, microglia containing LDs exhibit altered functionality, including increased oxidative stress, heightened proinflammatory signaling, and reduced phagocytic capacity (Marschallinger et al., 2020

Integrative Potential and Clinical Insight From a functional medicine perspective, GLP-1, GLP-2, and VIP peptides could become adjunctive supports in MCAS and related conditions such as IBS, POTS, EhlersDanlos syndrome, chronic fatigue, and long COVID, where mast-celldriven neuroinflammation plays a central role