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Oxidative stress is markedly increased in patients with COPD, especially during acute exacerbations, and contributes to the pathology of the disease [12, 13]

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These actions included down-regulation of Wnt signaling pathway [416], regulation of gut microbiota diversity [417], regulation of arginine metabolism in macrophages [418], modulation of SUMO1 through the Wnt/-catenin pathway [419], inhibition of STAT3 O-GlcNAcylation and reduction JAK2/STAT3 pathway activity [420], suppression of the intestinal inflammatory cascade reaction, and regulation of autophagy and SIRT1/mTOR signaling [421,422], modulation of the PI3K/Akt/VEGFA pathway [423], reduction of neutrophil infiltration, inhibition of adhesive molecules, restoration of the NO and redox status [424,425], recovery of the Treg/Th17 balance and the HIF-1/mTOR signaling pathway [426], induction of immunosuppressive CD11b(+) Gr-1(+) cells [427] promotion of MUC2 synthesis via the ANRIL-miR-34a axis [427], NLRP-3 inflammasome repression [428], AMPK-mediated activation of CDX2 and the regulation of the SIRT1/NF-B pathway [429], downregulation of miR-31 [430,431], inhibition of SphK1 , and downregulation of the p38 MAPK [432]

These curcumin formulations were found to be safe and well-tolerated even at higher doses ranging from 2 g/day to 12 g/day and for a prolonged duration of 6 months to an year