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Low levels of IGF-1 are associated with reduced cognitive function 32 , with the age-related decline in IGF-1 possibly contributing to cognitive decline and increased risk of dementia 33,34

These groups would need to ensure they are getting adequate calcium, vitamin D and magnesium through their diet as these are critical for bone health

The death receptor pathway directly activates caspase-8 by forming the Fas/tumor necrosis factor receptor 1 (TNFR1)-death inducing signaling complex, thereby activating caspase-3 or promotes apoptosis by amplifying the mitochondrial pathway (Li H