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Transgenic overexpression of Sry sensitizes mice to APAP-induced liver damage and apoptosis, whereas hepatocyte-specific knockout of Sry protects against these conditions We previously reported the generation of hepatocyte-specific Sry transgenic mice ( Sry- TG) overexpressing Sry in hepatocytes under the control of the albumin (Alb) gene promoter [17], as well as hepatocyte-specific Sry knockout mice ( Sry HC ) generated by crossbreeding SRY flox mice ( Sry fl/fl ) with Alb-Cre transgenic mice [18]

Studies have revealed the mechanisms of the combined therapy with ATRA and arsenic trioxide

ILK5 S192A , ILK5 S192D , MKK4 K108R , MKK5 K99R and MKK5 K99RT215AS221A were generated by site-directed mutagenesis following the manufacturers protocol (Invitrogen, Platinum SuperFi DNA polymerase)

It is known adversely affecting the productivity and even survival of the agricultural ecosystem, especially in rain-fed lowlands of the world (Siddiqui et al., 2021)

Molecular dynamics simulations suggest novel allosteric modes in the Hsp70 chaperone protein