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A study investigating d-aspartate metabolism in the brain and serum of rats with ASD that the levels of mRNA of d-aspartate oxidase, which encodes the enzyme, responsible for d-aspartate catabolism, significantly lowered [61]

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Given potential hepatotoxicity, azathioprine is avoided in the setting of high bilirubin and acute liver failure

Recent studies have also explored the use of combination therapies that incorporate novel agents targeting specific cellular mechanisms, such as mitophagy ( Future research may focus on identifying optimal drug combinations tailored to individual patient profiles