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Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

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Under HO-induced oxidative stress, the expression levels of -catenin and its downstream effector CDH3 are markedly reduced in melanocytes, thereby weakening their antioxidant responses [135].Vitamin D treatment reverses this suppression by promoting Ser9 phosphorylation of GSK3, thereby preventing -catenin degradation and activating downstream transcriptional programs

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Effect of social status on patterns of oxidative stress in the brain We evaluated the effect of social status on multiple markers of oxidative stress (TAC, total glutathione, oxidative DNA damage) in the telencephalon, midbrain, hindbrain, and hypothalamus (Figure 2a)