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The response to genetic ( UBE2I KD ) or pharmacological (ML792 and SAMe) inhibition of SUMOylation was assessed in vitro and in two in vivo models of CCA

So far we lack a comprehensive mechanistic picture of the dynamics of the glutathione pool in the IMS, including its crosstalk with neighbouring compartments and redox pathways

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Polyphenolic fraction obtained from Thalassia testudinum marine plant and thalassiolin B exert cytotoxic effects in colorectal cancer cells and arrest tumor progression in a xenograft mouse model