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doi: 10.1046/j.1365-2605.1998.00106.x 145 CambiMTamburrinoLMarchianiSOlivitoBAzzariCFortiGet al

The option of using single dose vaccines, which do not require thimerosal, is not feasible for some countries because of limits in the production of single-dose vaccines and lack of infrastructure for the transportation and storage of single-dose vials in a cold-chain system

Weeks 1-4: 2mg once weekly

Subsequent efforts to improve the therapeutic index led to the development of JHU083, an orally bioavailable DON prodrug, which has thus far been evaluated only in preclinical models [168]

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