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10.1016/S0092-8674(00)00182-3 [DOI] [PubMed] [Google Scholar] Gallant J, Irr J, Cashel M

doi: 10.1210/endocr/bqad155 163 ChristoffoleteMARibeiroRSingruPFeketeCda SilvaWSGordonDFet al

16 As folate is essential for production of purines and pyrimidines, the nucleotide precursors of RNA and DNA, low folate levels can result in abnormalities in cellular proliferation, as well as transcription and translation, and therefore contribute to DNA instability 17 and chromosome breakage