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The multifaceted status of DRE patients underscores the emphasis on non-pharmacological options, and therapies that target multiple mechanisms are likely to be more effective to treat DRE ( Clinical studies show that both modalities (VNS and KD) lead to a seizure frequency reduction (SFR) by at least 50% in half of the DRE patients

An indirect NRF2 activator through Bach1 derepression was developed to overcome these problems and relieved MPTP-induced neurodegeneration and associated oxidative stress [94]

Wei et al., 2021)

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

This might possibly be due to the engineered control circuits responding to the target product intermediate, limiting any improvement in production beyond initial control levels