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When present, side effects are typically mild and transient, potentially including slight drowsiness if administered too early (easily resolved by timing adjustment), mild headaches during initial adaptation in some individuals (usually resolving within days), temporary vivid dreams as sleep architecture normalizes, or rare reports of mild dizziness upon waking in sensitive individuals

The other major cause of altered epigenetic regulation is due to diet

10.1016/J.BBRC.2009.10.025 72 HemmatiS.SadeghiM

(2019) 144:10917.e4

The frailty reduction signal is more translationally relevant, as frailty is a recognized clinical syndrome in aging humans