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Homeostasis in mitochondrial mass and tissue energetic demands requires biogenic synthesis of new mitochondrial components to be spatiotemporally matched with the removal of old/damaged mitochondria (229)

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Annu Rev Biochem 1983, 52:711760

1 Introduction Multiple myeloma (MM) is characterized by the clonal expansion of CD138 + /CD38 + plasma cells within a hypoxic, acidic bone marrow (BM) niche that supports tumor growth through extensive intercellular signaling ( The development of CD38-targeted therapies is complicated by the multifunctionality of the molecule

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