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This is called a biphasic or hormetic dose-response common in biology

Excess B vitamins are excreted by the kidneys through the urine, causing bright yellow urine

Louis Post-Dispatch

doi: 10.3389/fimmu.2021.694217 70 LiQGaoBSiqinBHeQZhangRMengXet al

[3] [4] Clinical trials have demonstrated substantial reductions in hemoglobin A1c (up to 2.5% reduction from baseline) and body weight (up to 20% reduction from baseline) in the SURPASS and SURMOUNT clinical trial programs